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Abstract Detail



Phytochemical Section

kanu, Richard [1], Shonubi, Olusola [1], Ariyo, Ayodele [1], Oloyede, Adeola [1].

Investigating the probable potential of the Moss plant Wijkia trichocolea Mull.Hal against the mice Rattus albus induced with cancer agent 7,12 dimethylbenzene Anthrancene.

The effectiveness of the moss plant Wijkia trichocolea Mull.Hal extract was tested against the mice Rattus albus induced with cancer agent 7,12 dimethylbenzene Anthrancene. The mice were bred in the animal house at the University of Lagos. They were divided into nine groups with four mice in each group. The Acute Toxicity of the moss plant extract were tested on five groups designated CA, CB, CC, CD and CE which were  administered 100mg/ml, 200mg/ml, 400mg/ml, 800mg/ml and 1000mg/ml of the moss plant extract respectively  according to their body weight. Two out of the four groups left designated CF and CG were induced with 0.5mg/ml of the cancer agent and 100mg/ml and 200mg/ml of the plant extract respectively throughout the experiment. The last two groups designated CH and CI served as the positive and negative controls respectively. The positive control group were induced with cancer agent and did not receive the plant extract while negative control group were not induced with the cancer agent and also receive no plant extract.  After eight weeks, two mice from each group were dissected and their various organs were subjected to Hematoxylin- eosin staining test to observe the effects of the treatments. The phytochemical screening of the plant extract was also carried out. The Acute Toxicity Test revealed that there was no death of the mice after 48hours. The Hematoxylin-eosin staining test reveal that there was no trace of the cancer agent in groups CF and CG which were induced with the cancer agent and 100mg/ml and 200mg/ml of the moss plant extract. The organs of mice in the positive control group revealed lesion while those of negative control group were normal. The qualitative phytochemical screening of the plant revealed that it contained flavonoids, tannins, glycosides, phenols, sugars and phlobatannin while the quantitative tests revealed that glycoside was the highest bio-active compound in the extract followed by tannin, flavonoid, sugar and phenol respectively. These results suggest that the moss plant Wijkia trichocolea Mull.Hal maybe a good candidate for further screening against cancer.


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1 - University of Lagos, Botany, Akoka, Yaba, Lagos, Nigeria

Keywords:
Moss Plant Extract
Cancer
Wijkia trichocolea Mull.Hal
Rattus albus
phytochemicals
Glycoside.

Presentation Type: Poster:Posters for Sections
Session: P
Location: Eyrie/Boise Centre
Date: Monday, July 28th, 2014
Time: 5:30 PM
Number: PPH003
Abstract ID:272
Candidate for Awards:None


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